Raggedy Ann meets Raggedy Andy for the first time; illustrated by Johnny Gruelle
According to Wikipedia.com Raggedy Ann was created by Johnny Gruelle (1880 - 1938) for his daughter, Marcella. She died at the age of 13 after being vaccinated at school for smallpox without her parents consent. Authorities blamed her death on a heart defect, but her parents blamed the vaccine. As a result, Gruelle became a very vocal opponent of vaccination and by association Raggedy Ann became the symbol for the anti-vaccination movement.